Hangover Research - Alcohol, Treatment, Drugs, Effects

Hangover Research Today is a free monthly online journal that collates and summarizes the latest research about Hangover, including details on alcohol, treatment, drugs, effects.


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Association of alcohol consumption with the risk of ocular trauma.

Han SB, Yang HK, Woo SJ, Hyon JY, Hwang JM

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

This study was conducted to evaluate the influence of alcohol consumption on the risk of ocular trauma. We retrospectively reviewed the medical records of 1,024 patients who visited emergency department and received ophthalmologic examination from January 1 to December 31, 2009. The patients were divided into 2 groups: those with ocular trauma (n = 494) and those without (n = 530); the influence of alcohol consumption was compared between these 2 groups. In the ocular trauma group, the association of the causes and types of ocular trauma with alcohol consumption was evaluated. One of 530 patients of no trauma group and 117 (23.7%) of 494 patients of trauma group were related with alcohol intake, and the difference was statistically significant (P < 0.001). Concerning the causes, physical assault was significantly more common in alcohol-associated injury (P < 0.001). Regarding the types of injury, orbital wall fracture and hyphema showed a significant association with alcohol consumption (P < 0.001). Older age and nighttime injury were significantly related to the increased risk of alcohol-associated ocular trauma (P = 0.018 and < 0.001, respectively). In conclusion, alcohol consumption significantly increases the risk of ocular trauma.

Published 2 May 2011 in J Korean Med Sci, 26(5): 675-8.
Full-text of this article is available online (may require subscription).


Articles on Hangover published 2 May 2011:

The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: A comprehensive review.   Clin Psychol Rev, 31(5): 800-816.

Since 2005, a rapidly expanding literature has evaluated whether environmental factors such as socio-cultural context and adversity interact with genetic influences on drinking behaviors. This article critically reviews empirical research on alcohol-related genotype-environment interactions (GxE) and provides a contextual framework for understanding how genetic factors combine with (or are shaped by) environmental factors to influence the development of drinking behaviors and alcohol use ... [Abstract] [Full-text]


Articles on Hangover published 28 April 2011:

Association between Alcohol Consumption and Cancers in the Chinese Population-A Systematic Review and Meta-Analysis.   PLoS One, 6(4): e18776.

[Abstract] [Full-text]

MnSOD Overexpression Prevents Liver Mitochondrial DNA Depletion after an Alcohol Binge but Worsens This Effect after Prolonged Alcohol Consumption in Mice.   Dig Dis, 28(6): 756-75.

Both acute and chronic alcohol consumption increase reactive oxygen species (ROS) formation and lipid peroxidation, whose products damage hepatic mitochondrial DNA (mtDNA). To test whether manganese superoxide dismutase (MnSOD) overexpression modulates acute and chronic alcohol-induced mtDNA lesions, transgenic MnSOD-overexpressing (TgMnSOD(+++)) mice and wild-type (WT) mice were treated by alcohol, either chronically (7 weeks in drinking water) or acutely (single intragastric dose of 5 g/kg). ... [Abstract] [Full-text]


Articles on Hangover published 27 April 2011:

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.   Proc Natl Acad Sci U S A, 108(17): 7119-24.

Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imputed SNPs with alcohol consumption (gram per day per kilogram body weight) among 12 population-based samples of European ancestry, comprising 26,316 individuals, with replication genotyping in an additional 21,185 individuals. SNP rs6943555 in ... [Abstract] [Full-text]

The enduring influence of drinking motives on alcohol consumption after fateful trauma.   Alcohol Clin Exp Res, 35(5): 1004-10.

Objective:  Drinking motives predict later levels of alcohol consumption and development of alcohol dependence, but their effects on stress-related drinking are less clear. Proximity to the terrorist attack on the World Trade Center (WTC) on 9/11/01 was significantly associated with alcohol consumption 1 and 16 weeks after 9/11/01. We investigated the relationship between drinking motives measured a decade earlier, proximity to the WTC, and drinking after 9/11/01. This event constitutes a ... [Abstract] [Full-text]

Acetaldehyde Burst Protection of ADH1B*2 Against Alcoholism: An Additional Hormesis Protection Against Esophageal Cancers Following Alcohol Consumption?   Alcohol Clin Exp Res, 35(5): 806-10.

This account of recent work presented at the 4th International Symposium on Alcohol Pancreatitis and Cirrhosis reports animal studies aimed at determining the role of the "acetaldehyde burst," generated shortly upon ethanol intake, as the mechanism of protection against alcoholism conferred by the ADH1B*2 polymorphism. Literature studies discussed suggest an additional role of the acetaldehyde burst on the paradoxical (hormesis) protection of the ADH1B*2 polymorphism against ... [Abstract] [Full-text]


Articles on Hangover published 25 April 2011:

Melatonin agonists in primary insomnia and depression-associated insomnia: Are they superior to sedative-hypnotics?   Prog Neuropsychopharmacol Biol Psychiatry.

Current pharmacological treatment of insomnia involves the use of sedative-hypnotic benzodiazepine and non-benzodiazepine drugs. Although benzodiazepines improve sleep, their multiple adverse effects hamper their application. Adverse effects include impairment of memory and cognitive functions, next-day hangover and dependence. Non-benzodiazepines are effective for initiating sleep but are not as effective as benzodiazepines for improving sleep quality or efficiency. Furthermore, their ... [Abstract] [Full-text]

Excessive alcohol consumption increases risk taking behaviour in travellers to Cusco, Peru.   Travel Med Infect Dis, 9(2): 75-81.

The risks associated with alcohol intoxication are rarely discussed during pre-travel counselling. However, alcohol immoderation abroad may increase the exposure to health risks. Few studies have addressed alcohol consumption and risk taking behaviour in travellers to South America. From October to December of 2004, travellers leaving the city of Cusco in Peru were asked to fill out anonymous questionnaires regarding demographics, self-reported alcohol consumption, illness and risk behaviour ... [Abstract] [Full-text]


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Hangover Research Today Archive:

Volume 1 (2004)
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Volume 3 (2006)
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Volume 5 (2008)
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Volume 6 (2009)
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Volume 7 (2010)
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Volume 8 (2011)
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